These data suggest that alprazolam is potentially more toxic in overdose than other benzodiazepines. In 2020, benzodiazepine overdose ED visits more often involved females (51.5%) and persons aged 25–34 years (20.9%); nearly one quarter (22.8%) also involved opioids (Table). All relative rate changes were statistically significant. From 2019 to 2020, benzodiazepine overdose visits per 100,000 emergency department visits increased (23.7%), both with (34.4%) and without (21.0%) opioid co-involvement.

  1. During January–June 2020, 92.7% of benzodiazepine-involved deaths also involved opioids, and 66.7% involved illicitly manufactured fentanyls.
  2. If you need help remembering to take your dose of Xanax on time, try using a medication reminder.
  3. For this reason, benzodiazepines like Xanax are Schedule IV controlled substances.
  4. Here you will find the lethal dose for some of the most commonly misused drugs, including illicit, prescription, and over-the-counter drugs.

Generic alprazolam comes as a tablet, extended-release tablet, orally disintegrating tablet, and oral liquid concentrate. Xanax is a brand-name drug that contains the active drug alprazolam. This active drug is also available as a generic medication. To help make sure that you do not miss a dose, try using a medication reminder.

A substance use disorder can significantly impact your health, relationships and overall quality of life. If you feel like you’re becoming dependent on Xanax or are taking it more than what your healthcare provider has prescribed, seek help as soon as possible. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Taking Xanax with an opioid may cause severe side effects. These can include excessive sleepiness, breathing problems, coma, and in rare cases, death.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated 3 Mar 2024), Cerner Multum™ (updated 17 Mar 2024), ASHP (updated 20 Mar 2024) and others. Xanax is a federal controlled substance (C-IV) because it can be abused or lead to dependence. Keep this medicine in a safe place to prevent misuse and abuse. Selling or giving away this Xanax may harm others, and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription medicines or street drugs.

Alprazolam overdose

If you suddenly stop taking a drug that your body has become dependent on, you could experience side effects known as withdrawal symptoms. You should take Xanax exactly as prescribed by your doctor. It’s important that you do not increase your dose or take more than prescribed unless you first talk with your doctor.

During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988. This system helps regulate breathing, actions, thinking, and more. If you drink alcohol, it’s best to avoid drinking it while taking Xanax. Alcohol and Xanax can reduce the activity of your central nervous system (CNS).

However, if a person can’t be woken up, has trouble breathing, or has a seizure, they will need immediate medical treatment. Someone overdosing on Xanax may need emergency care, so it’s crucial to recognize the warning signs. Because Xanax is a depressant, it causes nervous system depression. Muscle weakness, sedation, and slurred speech are common symptoms. Mixing Xanax with other depressants or taking it in high doses can cause someone to lose consciousness.

Lethal Dose Of Xanax: How Much Xanax Is Fatal?

This list does not contain all drugs that may interact with Xanax. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Drug-condition interactions can also cause certain effects.

Another drug used for this purpose is Valium (diazepam), which (like Xanax) is a benzodiazepine. Find out more about the similarities and differences between Xanax and Valium in this article. This article describes the dosages of Xanax, alcohol withdrawal as well as its strengths and how to take it. Isbister, Geoffrey K.; O’Regan, Luke; Sibbritt, David; Whyte, Ian M. “Alprazolam is relatively more toxic than[…]s in overdose.” British Journal of Clinical Pharmacology, July 2004.

“Alarming spike in fentanyl-related overd[…]ublic warning.” August 6, 2020. There is a causal relationship between obesity and slower metabolism, since eating unhealthy food for extended addiction among males periods of time can slow down the metabolism as it becomes clogged with fatty tissue. Because of this, the more you weigh, the more Xanax is necessary to result in an overdose.

What if you combine Xanax with another drug or medication?

As of 2018, Xanax was the 37th most commonly prescribed medication in the United States, with more than 20 million prescriptions written for it. If you take this medication as it’s intended — it’s commonly prescribed to treat anxiety or panic disorders — you may feel “normal” after your first dose. If you have withdrawal symptoms after your doctor has reduced your dose or had you stop treatment with Xanax, talk with them. Your doctor may increase your dosage again and then reduce it more slowly. However, if you have serious withdrawal symptoms, contact your doctor right away. If your symptoms feel life threatening, call 911 or your local emergency number immediately.

The higher a person’s body weight, the more Xanax is needed to achieve the same effect. Prescription drugs, no matter which kind, always come with certain instructions that detail how much is to be taken, when it should be ingested, and in what manner. The first and most obvious factor to consider when examining the risk of overdose is, of course, how much Xanax is used. Usual dosage levels for Xanax begin at 0.25 mg and can range all the way up to 10 mg for heavier dosages. American Addiction Centers (AAC) is committed to delivering original, truthful, accurate, unbiased, and medically current information.

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